2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W104868
    4-Iodobenzylamine hydrochloride
    4-Iodobenzylamine hydrochloride ((4-Iodophenyl)methanamine hydrochloride) is a probe that can detect the binding patterns of serine proteases that are like trypsin, as well as urokinase-type plasminogen activator (uPA).
    4-Iodobenzylamine hydrochloride
  • HY-W018781R
    Benzamidine hydrochloride (Standard)
    		Inhibitor
    Benzamidine hydrochloride (Standard) is the analytical standard of Benzamidine (hydrochloride). This product is intended for research and analytical applications. Benzamidine hydrochloride is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results.
    Benzamidine hydrochloride (Standard)
  • HY-185463
    β-Tryptase-IN-1
    		Inhibitor
    β-Tryptase-IN-1 is a selective β-tryptase inhibitor with a Ki of 10 nM. β-Tryptase-IN-1 binds to the inducible S4+ pocket unique to β-tryptase. β-Tryptase-IN-1 can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD).
    β-Tryptase-IN-1
  • HY-N13950
    Bacithrocin A
    		Inhibitor
    Bacithrocin A is a thrombin inhibitor that inhibits thrombin, factor Xa, trypsin and Papain with IC50s of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively.
    Bacithrocin A
  • HY-P991629
    C1 Esterase Inhibitor (Human)
    		Inhibitor
    C1 Esterase Inhibitor (Human) is a C1 Esterase inhibitor derived from human plasma. C1 Esterase Inhibitor (Human), a glycoprotein, is a serum protease inhibitor (serpin) that binds covalently and inactivates C1r, C1s, and mannan-binding protein-associated proteases (MASPs). C1 Esterase Inhibitor (Human) has anti-inflammatory effects. C1 Esterase Inhibitor (Human) can be used to prevent angioedema attacks associated with hereditary angioedema.
    C1 Esterase Inhibitor (Human)
  • HY-33900R
    Dihydrofuran-3(2H)-one (Standard)
    		Inhibitor
    Dihydrofuran-3(2H)-one (Standard) is the analytical standard of Dihydrofuran-3(2H)-one. This product is intended for research and analytical applications. Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) is a cyclic ketone that can be used to synthesize cyclic ketone inhibitors that inhibit the serine protease plasmin.
    Dihydrofuran-3(2H)-one (Standard)
  • HY-109127R
    Berotralstat (Standard)
    		Inhibitor
    Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.
    Berotralstat (Standard)
  • HY-159847
    Nacresertib
    		Inhibitor
    Nacresertib is a Ser/Thr Protease inhibitor.
    Nacresertib
  • HY-E70230
    Staphylokinase, staphylococcus aureus
    		Activator
    Staphylokinase, staphylococcus aureus (SAK) is a fibrin-specific plasminogen activator. Staphylokinase is an efficient, fibrin-selective thrombolytic agent.
    Staphylokinase, staphylococcus aureus
  • HY-W426308
    Chymotrypsin-IN-1
    		Inhibitor
    Chymotrypsin-IN-1 (Compound TPCK) is a chymotrypsin inhibitor. Chymotrypsin-IN-1 can irreversibly inhibit chymotrypsin-like serine proteases.
    Chymotrypsin-IN-1
  • HY-129027
    Ac-Leu-Gly-Lys(Ac)MCA
    Ac-Leu-Gly-Lys(Ac)MCA is a Trypsin fluorescence substrate.
    Ac-Leu-Gly-Lys(Ac)MCA
  • HY-169817
    PAR-2-IN-2
    		Inhibitor
    PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC50 of 10.79 μM for SLIGKV and an IC50 of greater than 200 μM for Trypsin.
    PAR-2-IN-2
  • HY-P990524
    Anti-TMPRSS2 Antibody
    		Inhibitor ≥99.0%
    The Anti-TMPRSS2 Antibody is a CHO-expressed humanized antibody that targets TMPRSS2. The Anti-TMPRSS2 Antibody features a huIgG1 heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. For the isotype control of the Anti-TMPRSS2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-TMPRSS2 Antibody
  • HY-111286
    WNK-IN-2
    		Inhibitor
    WNK-IN-2 is an ATP-competitive WNK kinase inhibitor with low kinase selectivity.
    WNK-IN-2
  • HY-179708
    Cbz-QFR-kbt
    		Inhibitor
    Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM). Cbz-QFR-kbt can be used in antiviral research.
    Cbz-QFR-kbt
  • HY-D0837R
    Imidazole (Standard)
    		Inhibitor
    Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
    Imidazole (Standard)
  • HY-B1624
    Debrisoquin
    		Inhibitor
    Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research.
    Debrisoquin
  • HY-P2033
    Nostopeptin B
    		Inhibitor
    Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against elastase and chymotrypsin.
    Nostopeptin B
  • HY-106448
    Midesteine
    		Inhibitor
    Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research.
    Midesteine
  • HY-108285R
    (Rac)-Telmesteine (Standard)
    		Inhibitor
    (Rac)-Telmesteine (Standard) is the analytical standard of (Rac)-Telmesteine (HY-108285). This product is intended for research and analytical applications. (Rac)-Telmesteine is a protease inhibitor and is thus a suitable enzyme stabilizer extracted from patent WO 2017220302 A1, compound II-1. (Rac)-Telmesteine can be used as an enzyme stabilizer in protease-containing detergents and cleaning agents.
    (Rac)-Telmesteine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity